Dimethyl malonate → HCID 57619583, compound

Temperature

80 °C

Under ice cooling, 568 mg of sodium hydride (60%) was added to a mixture of 181 mg of dimethyl malonate and 70 ml of N,N-dimethylformamide, and the mixture was stirred for 20 minutes. After the mixture was heated to 80° C., 1.50 g of 3-methyl-2H-1,3-oxazine-2,6(3H)-dione was added to the mixture, followed by further stirring at 120° C. for 7 hours. The reaction mixture was concentrated under reduced pressure, 2 mol/L hydrochloric acid was added to the residue, and the mixture was stirred at 60° C. for 15 minutes. The mixture was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, dried with sodium sulfate, filtered, and concentrated. The residue was subjected to silica gel column chromatography (eluent: ethyl acetate) to obtain 100 mg of methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate represented by the formula:

1. stirringby further stirring at 120° C. for 7 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure, 2 mol/L hydrochloric acid
3. additionwas added to the residue
4. stirringthe mixture was stirred at 60° C. for 15 minutes
5. extractionThe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with an aqueous saturated sodium chloride solution
7. dry with materialdried with sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated

ORD record

ord-ffb28f3aba5e4c3e9ad7f8e9cd171420

Source dataset

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07943614B2