反应详情

A mixture of methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate a51 (3.48 g, 14.8 mmol, 1 eq), potassium carbonate (4 g, 29.6 mmol, 2 eq) and 1-bromo-3-chloropropane a2 (1.6 ml, 16.2 mmol, 1.1 eq) in acetone (80 ml) is stirred at reflux overnight. The mixture is concentrated under vacuum then the residue is dissolved in ethyl acetate, and washed with a saturated solution of aqueous sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 2.3 g of methyl 1-[4-(3-chloropropoxy)phenyl]-5-oxopyrrolidine-3-carboxylate a53 as a yellow oil.

1. temperatureat reflux overnight
2. concentrationThe mixture is concentrated under vacuum
3. dissolutionthe residue is dissolved in ethyl acetate
4. washwashed with a saturated solution of aqueous sodium hydrogenocarbonate
5. dry with materialThe organic layer is dried over magnesium sulfate
6. concentrationconcentrated under vacuum