反应详情

Lithium hydroxide monohydrate (13 mg, 0.3 mmol) in water (2.5 mL) was added to a solution of methyl 3-[(3-methyl-4-oxo-3,4-dihydro-2H-1,3-benzoxazin-7-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]benzoate (0.12 g, 0.3 mmol) in THF (5 mL) and stirred at RT for 20 hours. The THF was removed in vacuo and the aqueous layer was washed with ethyl acetate (50 mL) to remove any impurities. The aqueous layer was acidified and extracted into ethyl acetate (2×50 mL), washed with brine (50 mL), dried (MgSO4), and the solvent removed in vacuo to give the desired compound as a white solid (110 mg).

1. customThe THF was removed in vacuo
2. washthe aqueous layer was washed with ethyl acetate (50 mL)
3. customto remove any impurities
4. extractionextracted into ethyl acetate (2×50 mL)
5. washwashed with brine (50 mL)
6. dry with materialdried (MgSO4)
7. customthe solvent removed in vacuo