3,6-Dibromopyridazine → 3-Bromo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine

HRID 548806Notes

Reaction equation

HRID 548806 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].[Br:15][C:16]1[N:17]=[N:18][C:19](Br)=[CH:20][CH:21]=1>>[Br:15][C:16]1[N:17]=[N:18][C:19]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 2488523,6-DibromopyridazineHCID 2776149(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol

Product 1

HCID 426296533-Bromo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazineYield 89%

Procedure

As described for example 1, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (2.46 g, 13 mmol) was converted using 3,6-dibromopyridazine instead of 3,6-dichloropyridazine to the title compound (3.99 g, 89%) as a white solid. MS: m/e=348.0/346.1 [M+H]+.

Sources & evidence

ORD record
ord-883c77a502ba472a9efb879101a353a1
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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