Methylamine → HCID 42630625, compound

HRID 548896Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[CH3:26][NH2:27]>>[CH3:26][NH:27][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5]

Participants

Reactant 2

HCID 6329Methylamine

HCID 67157617HCID 67157617, compound

Product 1

HCID 42630625HCID 42630625, compoundYield 17%

Procedure

As described for example 69, 6-(5-methyl-3-pyridin-4-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid ethyl ester (100 mg, 0.29 mmol) was converted, using methylamine (2 M solution in THF) instead of isopropylamine, to the title compound (16 mg, 17%) which was obtained as a white solid. MS: m/e=326.1 [M+H]−.

Sources & evidence

ORD record: ord-b236dbf951f744a4b193c354bef45809
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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