Ethanolamine → HCID 24903522, compound

HRID 548955Notes

Reaction equation

HRID 548955 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH2:10]([CH2:12][NH2:13])[OH:11].C(N(CC)CC)C>C(#N)C>[Br:1][C:2]1[C:3]([NH:13][CH2:12][CH2:10][OH:11])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 24903522HCID 24903522, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In analogy to compound 1.1, a solution of 0.34 g (1.49 mmol) of 5-bromo-2,4-dichloropyrimidine in 5 ml of acetonitrile is reacted with 0.1 ml (1.61 mmol) of ethanolamine in the presence of 0.25 ml (1.81 mmol) of triethylamine. Recrystallization from hexane/ethyl acetate 7/3 results in 0.28 g (74% of theory) of the product.

Workup

  1. customRecrystallization from hexane/ethyl acetate 7/3
  2. customresults in 0.28 g (74% of theory) of the product

Sources & evidence

ORD record
ord-f9ad1295549a42229df1c288f88a4901
Source dataset
uspto-grants-2011_05
Patent number
US07943629B2

Reaction notes

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