Potassium Cyanide → HCID 22477362, compound

HRID 549059Notes

Reaction equation

HRID 549059 reaction equation
[C-:1]#[N:2].[K+].[I-].C[N+](C)(C)[CH2:7][C:8]1[C:16]2[C:11](=[N:12][CH:13]=[CH:14][N:15]=2)[NH:10][C:9]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O.CN(C)C=O>[C:17]1([C:9]2[NH:10][C:11]3=[N:12][CH:13]=[CH:14][N:15]=[C:16]3[C:8]=2[CH2:7][C:1]#[N:2])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 22477336HCID 22477336, compound

Product 1

HCID 22477362HCID 22477362, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6228DimethylformamideSolvent

Conditions

Temperature
75 °C

Procedure

A solution of potassium cyanide (0.84 g) in water (20 mL) was added rapidly to a stirred solution of trimethyl-(6-phenyl-5H-pyrrolo[2,3-b]pyrazin-7-ylmethyl)-ammonium iodide [1.1 g, Reference Example 33] in dimethylformamide (20 mL) and the mixture heated at 75° C. for 6 hours. The cooled solution was diluted with water (100 mL) and the precipitated solid filtered to give the title compound as a yellow solid, m.p. 247-248° C.

Workup

  1. filtrationthe precipitated solid filtered

Sources & evidence

ORD record
ord-aa63fbcad66e4a049b5d9e6bd0a80605
Source dataset
uspto-grants-2011_05
Patent number
US07943616B2

Reaction notes

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