Hydrazine hydrate (1:1) → 6-(s-Triazolo[4,3-a]pyridin-3-ylthio)hexylamine

HRID 54917Notes

Reaction equation

HRID 54917 reaction equation
[N:1]1[N:2]=[C:3]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N:17]2C(=O)C3=CC=CC=C3C2=O)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.O.NN>C(O)C>[N:1]1[N:2]=[C:3]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19956977HCID 19956977, compound

Product 1

HCID 199569956-(s-Triazolo[4,3-a]pyridin-3-ylthio)hexylamineYield 87.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-[6-(s-triazolo[4,3-a]pyridin-3-ylthio)hexyl]phthalimide (16.5 g), hydrazine monohydrate (4.34 g) and ethanol (135 ml) was heated under reflux for 1 hour. The deposited crystals were separated by filtration, and the filtrate was concentrated under reduced pressure to obtain 6-(s-triazolo[4,3-a]pyridin-3-ylthio)hexylamine as an oil. Yield: 87.5%.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. customThe deposited crystals were separated by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8dd4f6880f55484eb55f6522407ce1b0
Source dataset
uspto-grants-1997_04
Patent number
US05624917

Reaction notes

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