Hydrochloric Acid → HCID 57737264, compound

HRID 549432Notes

Reaction equation

HRID 549432 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:10]2[S:11][C:12]([C:14]([O:16]C(C)(C)C)=[O:15])=[CH:13][C:9]=2[C:8]([NH:21][C:22](=[O:37])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[NH:29][C:30]([C:32]2[NH:33][CH:34]=[CH:35][CH:36]=2)=[O:31])=[N:7]1)=[O:5])[CH3:2].Cl>O1CCOCC1>[CH2:1]([O:3][C:4]([N:6]1[C:10]2[S:11][C:12]([C:14]([OH:16])=[O:15])=[CH:13][C:9]=2[C:8]([NH:21][C:22](=[O:37])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[NH:29][C:30]([C:32]2[NH:33][CH:34]=[CH:35][CH:36]=2)=[O:31])=[N:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57737262HCID 57737262, compound

Product 1

HCID 57737264HCID 57737264, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The solution of 3-{2-[(1H-Pyrrole-2-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester (460.8 mg, 0.88 mmol) in dioxane (10 mL) was treated with HCl 4M in dioxane (10 mL) overnight, the solvent was then removed and the residue was triturated with diethylether (Et2O, 15 mL) yielding 397 mg (96%) of the product, LC-MS: Rt 3.7; [M+H]+ 468;

Workup

  1. customthe solvent was then removed
  2. customthe residue was triturated with diethylether (Et2O, 15 mL)

Sources & evidence

ORD record
ord-2a3fcdb7337a4928bf9460a8a63d170c
Source dataset
uspto-grants-2011_05
Patent number
US07943654B2

Reaction notes

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