反应详情

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (153 mg), dibenzoylmethane (162 mg) and conc. hydrochloric acid (0.1 ml) in ethanol (5 ml) was refluxed for 4 hours. The reaction mixture was cooled and poured into ice-water. The mixture was neutralized with an aqueous saturated sodium bicarbonate solution. The separated oil was extracted with dichloromethane and the extract was washed with brine, dried and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from methanol to give 5,7-diphenyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine (250 mg).

1. temperaturewas refluxed for 4 hours
2. temperatureThe reaction mixture was cooled
3. extractionThe separated oil was extracted with dichloromethane
4. washthe extract was washed with brine
5. customdried
6. concentrationconcentrated in vacuo
7. customThe residue was purified by column chromatography on silica gel
8. customthe obtained oil was crystallized from methanol