反应详情

A slurry of valsartan barium (90 g) in ethyl acetate (900 ml) and water (360 ml) was treated with hydrochloric acid to attain a pH of about 2 to 2.5. The organic layer was separated, washed with water (3×270 ml) and concentrated at about 45° to 50° C. under reduced pressure. The residue was dissolved in ethyl acetate (225 ml) at 45° to 50° C., filtered at hot condition and cooled to 20° to 25° C. Pentane (900 ml) was then added slowly to the mixture and stirred for 1 hour at 20° to 25° C. The solid obtained was filtered, washed with pentane (2×90 ml) and dried under reduced pressure to obtain the title compound.

1. customThe organic layer was separated
2. washwashed with water (3×270 ml)
3. concentrationconcentrated at about 45° to 50° C. under reduced pressure
4. dissolutionThe residue was dissolved in ethyl acetate (225 ml) at 45° to 50° C.
5. filtrationfiltered at hot condition
6. temperaturecooled to 20° to 25° C
7. additionPentane (900 ml) was then added slowly to the mixture
8. customThe solid obtained
9. filtrationwas filtered
10. washwashed with pentane (2×90 ml)
11. customdried under reduced pressure