Hydrogen Bromide → HCID 66631059, compound

HRID 550079Notes

Reaction equation

[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:27]=[C:26]([CH3:28])[O:25][N:24]=4)=[CH:17][CH:16]=3)[CH:7]=2)[CH2:3][CH2:2]1.[BrH:31]>>[BrH:31].[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]4[CH:27]=[C:26]([CH3:28])[O:25][N:24]=4)=[CH:19][CH:20]=3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 11463864HCID 11463864, compound

Product 1

HCID 66631059HCID 66631059, compound

Procedure

Using an analogous procedure to that described in Example 36, N-cyclopropyl-4-methyl-3-({4-[(5-methylisoxazol-3-yl)methoxy]benzoyl}amino)benzamide was reacted with hydrobromic acid to give the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.68 (m, 2H), 2.26 (s, 3H), 2.44 (5, 3H), 2.85 (m, 1H), 5.25 (s, 2H), 6.37 (s, 1H), 7.15 (m, 2H), 7.31 (m, 1H), 7.61 (m, 1H), 7.78 (s, 1H), 7.98 (m, 2H), 8.37 (s, 1H), 9.82 (s, 1H); Mass Spectrum: M−H− 404, M+Na+ 428.

Sources & evidence

ORD record: ord-690daceb8e9849d68ed9d797008866fb
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943776B2

Reaction notes

Loading…