反应详情

Treat 6-hydroxynaphthalene-2-carboxylic acid methyl ester (4.77 g, 23.6 μmmol) and benzyl bromide (3.3 mL, 28.3 mmol) in DMF (22 mL) with cesium carbonate (15.3 g, 47.2 mmol). Stir the mixture for 22 h at RT and concentrate. Dilute the concentrate with EtOAc (300 mL) and water (100 mL). Wash the organic layer with brine (3×100 mL), dry it over Na2SO4, and filter. Concentrate the filtrate. Purify the product using medium pressure silica gel chromatography (15:85 to 50:50 EtOAc:hex) to give the title compound as a white solid (5.75 g, 83%). MS (ES) m/e 293 (M+1).

1. concentrationconcentrate
2. additionDilute the
3. concentrationconcentrate with EtOAc (300 mL) and water (100 mL)
4. washWash the organic layer with brine (3×100 mL)
5. dry with materialdry it over Na2SO4
6. filtrationfilter
7. concentrationConcentrate the filtrate
8. customPurify the product