反应详情

Treat a mixture containing trifluoromethanesulfonic acid 6-(1-ethylpropenyl)naphthalen-2-yl ester (0.92 g, 2.67 mmol), Pd(OAc)2 (0.020 mg, 0.09 mmol), bis-(diphenylphosphino)ferrocene (0.046 g, 0.083 mmol), Et3N (0.67 mL, 4.81 mmol), in MeOH (10 mL) and DMSO (15 mL) with carbon monoxide at 100 psi at 80° C. for 4 h. Pour the reaction mixture into ether (100 mL) and wash the mixture with brine (4×50 mL). Dilute the organic layer with EtOAc (100 mL), wash with brine, then dry over Na2SO4 and filter. Concentrate the filtrate to give the title compound as an off-white solid (0.67 g, quant). MS (ES) in/e 255 (M+1).

1. additionTreat a mixture
2. washwash the mixture with brine (4×50 mL)
3. additionDilute the organic layer with EtOAc (100 mL)
4. washwash with brine
5. dry with materialdry over Na2SO4
6. filtrationfilter
7. concentrationConcentrate the filtrate