反应详情

Treat a solution of 6-{1-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]-1-ethylpropyl}naphthalene-2-carboxylic acid (0.15 g, 0.34 mmol) in THF (6 mL) with NaBH4 (0.025 g, 0.67 mmol) and stir the reaction mixture at RT for 1 h. Quench the reaction first with water (5 mL) and then with 1N HCl (2 mL). Remove the THF under vacuum. Dilute the mixture with EtOAc (50 mL), wash with brine (2×), dry over NaSO4 and filter. Concentrate the filtrate to give the title compound (0.15 g). MS (ES) m/e 447 (M−1).

1. customQuench
2. customthe reaction first with water (5 mL)
3. customRemove the THF under vacuum
4. additionDilute the mixture with EtOAc (50 mL)
5. washwash with brine (2×)
6. dry with materialdry over NaSO4
7. filtrationfilter
8. concentrationConcentrate the filtrate