Potassium Carbonate → HCID 58617244, compound

HRID 550363Notes

Reaction equation

HRID 550363 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13](=[O:24])[CH2:14][C:15]2[C:20]([F:21])=[CH:19][C:18]([F:22])=[CH:17][C:16]=2[F:23])=[C:10](CC)[CH:9]=[CH:8][N:7]=1)=[O:5])C.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[F:21][C:20]1[CH:19]=[C:18]([F:22])[CH:17]=[C:16]([F:23])[C:15]=1[CH:14]1[C:4](=[O:5])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][N:7]=2)[NH:12][C:13]1=[O:24]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 67200325HCID 67200325, compound

Product 1

HCID 58617244HCID 58617244, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

The product from Step 2 (0.80 g) and potassium carbonate (0.40 g) were stirred in dry DMF (10 ml) at 100° C. for 6 hours. The reaction mixture was cooled, stood for 18 hours and the DMF was evaporated to give a solid. This was diluted with water (1 ml), acidified to neutrality and the water was evaporated to give a solid, which was then extracted with methanol. The methanol was evaporated to give 3-(2,4,6-trifluorophenyl)-1H-[1,5]naphthyridine-2,4-dione as a peach coloured solid (0.15 g), which was used without further purification.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe DMF was evaporated
  3. customto give a solid
  4. customthe water was evaporated
  5. customto give a solid, which
  6. extractionwas then extracted with methanol
  7. customThe methanol was evaporated

Sources & evidence

ORD record
ord-351d97fea03c41e8a0b881599f366d42
Source dataset
uspto-grants-2011_05
Patent number
US07947679B2

Reaction notes

Loading…