Hydrochloric Acid → Hydrochloric Acid

HRID 550373Notes

Reaction equation

HRID 550373 reaction equation
[N:1]([C:4]1[C:5]([NH:11]C(=O)C(C)(C)C)=[N:6][CH:7]=[C:8]([F:10])[CH:9]=1)=[N+:2]=[N-:3].[ClH:18]>>[N:1]([C:4]1[C:5]([NH2:11])=[N:6][CH:7]=[C:8]([F:10])[CH:9]=1)=[N+:2]=[N-:3].[ClH:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22293288N-(3-Azido-5-fluoropyridin-2-yl)-2,2-dimethylpropanamide

Product 2

HCID 313Hydrochloric AcidHCID 222932423-Azido-5-fluoropyridin-2-amine

Procedure

N-(3-Azido-5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (275 mg, 1.16 mmol) in 3 N HCl (5 mL) was heated to 100° C. After 2 h, the volatiles were removed in vacuo, to give the title compound as its HCl salt (180 mg). MS: m/z=154.2 (M+1).

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-deeaae3c160149ee9b6319cb1530ca21
Source dataset
uspto-grants-2011_05
Patent number
US07947678B2

Reaction notes

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