反应详情

温度

80 °C

In 150 ml of DMF was dissolved 3.0 g (8.09 mmol) of 1,2,3,4-tetrahydro-6-nitro-2,4-dioxo-3-(4-piperidinyl)-quinazoline hydrobromide, and 1.7 g (8.09 mmol) of 4-chloro-6,7-dimethoxyquinazoline and 1.1 g (24 mmol) of potassium carbonate were added to the solution, followed by heating at 80° C. for 2 hours. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with an aqueous solution of sodium chloride and dried. After the solvent was distilled off, ethanol and ether were added to the residue. The precipitated crystals were collected by filtration and washed with ether to give 3.28 g (yield: 85%) of Compound 24 as white crystals.

1. additionwere added to the solution
2. extractionthe mixture was extracted with chloroform
3. washThe organic layer was washed with an aqueous solution of sodium chloride
4. customdried
5. distillationAfter the solvent was distilled off
6. additionethanol and ether were added to the residue
7. filtrationThe precipitated crystals were collected by filtration
8. washwashed with ether