Phosphorus oxychloride → HCID 59686245, compound

HRID 550783Notes

Reaction equation

[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]2[NH:14][C:13]3[CH2:15][S:16][CH2:17][C:12]=3[C:11](=O)[N:10]=2)=[C:4]([F:19])[CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:11]1[C:12]2[CH2:17][S:16][CH2:15][C:13]=2[N:14]=[C:9]([C:5]2[CH:6]=[C:7]([F:8])[C:2]([Cl:1])=[CH:3][C:4]=2[F:19])[N:10]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178517533HCID 178517533, compound

Product 1

HCID 59686245HCID 59686245, compound

Conditions

Temperature: 90 °C

Procedure

A mixture of 2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4(1H)-one and phosphorous oxychloride was stirred at 90° C. for 4 hours to yield 4-chloro-2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidine.

Sources & evidence

ORD record: ord-a8c55af0a48c47b18aa9d78e4aded153
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947690B2

Reaction notes

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