反应详情

To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.

1. temperaturemaintaining the temperature below 30° C
2. customto precipitate pyrrolidinium bromide, which
3. customwas separated by filtration
4. customThe filtrate was evaporated under vacuum
5. customto provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate