Chloride → HCID 59257860, compound

HRID 551057Notes

Reaction equation

HRID 551057 reaction equation
[Cl-].C([O:6][C:7](=[O:28])[CH2:8][N:9]1[C:17]2[C:12](=[C:13]([N+:18]([O-])=O)[CH:14]=[CH:15][CH:16]=2)[CH:11]([CH2:21][CH2:22][C:23](OCC)=[O:24])[CH2:10]1)(C)(C)C>>[O:24]=[C:23]1[NH:18][C:13]2[C:12]3[CH:11]([CH2:10][N:9]([CH2:8][C:7]([OH:6])=[O:28])[C:17]=3[CH:16]=[CH:15][CH:14]=2)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 312ChlorideHCID 86629735HCID 86629735, compound

Product 1

HCID 59257860HCID 59257860, compound

Procedure

Essentially following the procedures described for Intermediate 34, but using (±)-ethyl 3-[1-(2-tert-butoxy-2-oxoethyl)-4-nitro-2,3-dihydro-1H-indol-3-yl]propanoate in place of ethyl 3-[1-(2-tert-butoxy-2-oxoethyl)-4-nitro-1H-indol-3-yl]propanoate, and resolving the racemate into pure enantiomers in analogy with Intermediate 42, the title compound was prepared. MS: m/z=303 (M+1).

Sources & evidence

ORD record
ord-2c741f6ca93c461da4f7bf9a03393763
Source dataset
uspto-grants-2011_05
Patent number
US07947677B2

Reaction notes

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