HCID 131719996, compound → Benzoic Acid

HRID 55106Notes

Reaction equation

HRID 55106 reaction equation
C([O:8][C:9]([C:11]1[CH:12]=[C:13](NC(=O)NCC(N2C(C3C=CC=CC=3)CCC2(C)C(OC(C)(C)C)=O)=O)[CH:14]=[CH:15][CH:16]=1)=[O:10])C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[C:9]([OH:10])(=[O:8])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 1

HCID 131719996HCID 131719996, compound

Product 1

HCID 243Benzoic Acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A The reaction is carried out in a way similar to that described in Example 1A but starting from 0.54 g of tert-butyl (2RS,5SR)-1-{2-[3-(3-(benzyloxycarbonyl)phenyl)ureido]acetyl}-2-methyl-5-phenyl-pyrrolidine-2-carboxylate and 0.15 g of 10% palladium-on-charcoal in 30 cm3 of ethyl acetate. After treatment, there is obtained 0.25 g of (2RS,5SR)-3-3-2-(2-tert-butoxycarbonyl-2-methyl-5-phenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid melting at 150° C.

Sources & evidence

ORD record
ord-5001cac395fd434c864bc4aa4be9bade
Source dataset
uspto-grants-1997_04
Patent number
US05624939

Reaction notes

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