Hydrochloric Acid → HCID 67639963, compound

HRID 55108Notes

Reaction equation

Cl.[CH3:2][O:3][C:4](=[O:37])[C@@:5](C(NC(OC(C)(C)C)=O)C[C@@H](C)CC)([C@@H:7]([C:11]([CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][NH:14]1)=[O:12])[CH2:8][S:9][CH3:10])[NH2:6]>CCOC(C)=O>[CH3:2][O:3][C:4](=[O:37])[C@H:5]([C@@H:7]([C:11]([CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][NH:14]1)=[O:12])[CH2:8][S:9][CH3:10])[NH:6][CH2:4][C@@H:5]([NH2:6])[C@@H:7]([CH3:8])[CH2:11][CH3:13]

Participants

Conditions

Temperature: -20 °C

Procedure

HCl gas was bubbled into a solution of N-[2(S)-(t-butyloxycarbonylamino-3(S)-methylpentyl]-1,2,3,4-tetrahydro-3(S)-isoquinolinecarbonyl-methionine methyl ester (0.37 g, 0.71 mmol) in EtOAc (25 mL) with stirring at -20° C. over 0.5 h. The solution was purged with argon for 0.5 h, then concentrated to give the title compound as a white solid which was used without further purification.

Workup

customThe solution was purged with argon for 0.5 h
concentrationconcentrated

Sources & evidence

ORD record: ord-0c33e4a437ae4048a3f45156e67150e1
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624936

Reaction notes

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