4-Methylmorpholine → HCID 178492727, compound

HRID 551204Notes

Reaction equation

HRID 551204 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1=[O:18])[C:6]([OH:8])=O.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1.[Cl:48][C:49]1[CH:60]=[CH:59][C:52]2[NH:53][C:54]([C@@H:56]([NH2:58])[CH3:57])=[N:55][C:51]=2[CH:50]=1>CN(C=O)C>[Cl:48][C:49]1[CH:60]=[CH:59][C:52]2[NH:53][C:54]([C@@H:56]([NH:58][C:6](=[O:8])[C:5]3[CH:9]=[CH:10][C:11]([N:12]4[CH2:17][CH2:16][CH2:15][CH2:14][C:13]4=[O:18])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH3:57])=[N:55][C:51]=2[CH:50]=1

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 42034613(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 670493433-Methoxy-4-(piperidin-2-on-1-yl)benzoic acid

Product 1

HCID 178492727HCID 178492727, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1f from 3-methoxy-4-(piperidin-2-on-1-yl)benzoic acid, TBTU, NMM and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in DMF and subsequent purification by preparative HPLC.

Sources & evidence

ORD record
ord-a9a9007dd6d4492ca6311489836a0d94
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

Loading…