Trifluoroacetic acid → (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine

HRID 551215Notes

Reaction equation

HRID 551215 reaction equation

C([NH:8][C@H:9]([C:14]1[NH:18][C:17]2[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:16]=2[N:15]=1)[CH2:10][CH2:11][O:12][CH3:13])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>ClCCl>[Cl:23][C:21]1[CH:20]=[CH:19][C:17]2[NH:18][C:14]([C@@H:9]([NH2:8])[CH2:10][CH2:11][O:12][CH3:13])=[N:15][C:16]=2[CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178495124HCID 178495124, compound

Product 1

HCID 178495121(S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 1g from (1S)—N-Boc-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxy-propylamine and TFA in dichloromethane.

Sources & evidence

ORD record: ord-ba94615ce5184108849f489c1dfb3f74
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947700B2

Reaction notes

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