4-Methylmorpholine → HCID 178462087, compound

HRID 551220Notes

Reaction equation

HRID 551220 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH2:16][CH:15]=[CH:14][CH2:13][O:12]1)[C:5]([OH:7])=O.[Cl:17][C:18]1[CH:29]=[CH:28][C:21]2[NH:22][C:23]([C@@H:25]([NH2:27])[CH3:26])=[N:24][C:20]=2[CH:19]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH2:16][CH:15]=[CH:14][CH2:13][O:12]1)[C:5]([NH:27][C@H:25]([C:23]1[NH:22][C:21]2[CH:28]=[CH:29][C:18]([Cl:17])=[CH:19][C:20]=2[N:24]=1)[CH3:26])=[O:7]

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 42034613(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 670485203-Chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoic acid

Product 1

HCID 178462087HCID 178462087, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1f from 3-chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine, TBTU and NMM in DMF.

Sources & evidence

ORD record
ord-e4499e2aa607469192c4732deded286f
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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