Lithium Hydroxide → 3-Chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid

HRID 551260Notes

Reaction equation

HRID 551260 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[N:13]1[CH:18]([CH3:19])[CH2:17][O:16][CH2:15][C:14]1=[O:20])[C:5]([O:7]CC)=[O:6].[OH-].[Li+]>C1COCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[N:13]1[CH:18]([CH3:19])[CH2:17][O:16][CH2:15][C:14]1=[O:20])[C:5]([OH:7])=[O:6]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67049237Ethyl 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoate

Product 1

HCID 670485053-Chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 31b from ethyl 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoate with lithium hydroxide in THF and water.

Sources & evidence

ORD record
ord-9876d63282a346c4a0348042db0e36f6
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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