反应详情

温度

5 °C

To a solution of oxo-thiophen-2-yl-acetic acid (8 g, 51.2 mmol), suspended in DCM (80 ml) and cooled to 5° C., is added oxalylchloride (5.3 ml, 61.5 mmol), followed by DMF (0.1 ml). Stirring is continued for 1 hour at 5° C. and 18 hours at room temperature. The reaction mixture is evaporated to dryness, toluene is then added and the mixture evaporated once more to give the title compound as a dark oil.

1. customThe reaction mixture is evaporated to dryness, toluene
2. additionis then added
3. customthe mixture evaporated once more