Thiophene-3-carboxylic acid → N-Propyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-3-thiophenecarboxamide

HRID 551480Notes

Reaction equation

HRID 551480 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.[F:9][C:10]([F:37])([F:36])[C:11]([CH2:31][NH:32][CH2:33][CH2:34][CH3:35])([OH:30])[CH2:12][NH:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]2[C:15]=1[CH:16]=[N:17][N:18]2[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:33]([N:32]([CH2:31][C:11]([OH:30])([CH2:12][NH:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]2[C:15]=1[CH:16]=[N:17][N:18]2[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:10]([F:37])([F:36])[F:9])[C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8])[CH2:34][CH3:35]

Participants

3

Reactant 2

HCID 6918Thiophene-3-carboxylic acidHCID 593241271,1,1-Trifluoro-3-[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]-2-[(propylamino)methyl]-2-propanol

Product 1

HCID 59324164N-Propyl-N-(3,3,3-trifluoro-2-hydroxy-2-{[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]methyl}propyl)-3-thiophenecarboxamide

Procedure

Prepared similarly to Example 11 from 3-thiophenecarboxylic acid and 1,1,1-trifluoro-3-[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]-2-[(propylamino)methyl]-2-propanol.

Sources & evidence

ORD record
ord-1072d4112e6f4052bbad3b51183f7c4e
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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