Tetrahydrofuran → HCID 131728911, compound

An anhydrous tetrahydrofuran solution (2 mL) of (±)-(1S,5R)-5-methylbicyclo[3.2.0]hept-3-en-6-one (800 mg, 6.55 mmol) was added dropwise with stirring under ice cooling to a reaction solution prepared in advance from an anhydrous tetrahydrofuran solution (10 mL) of tert-butyl dimethylphosphorylacetate (1.28 g, 6.55 mmol) and sodium hydride (>63% oil, 245 mg, 6.55 mmol), and the mixture was then stirred for 1 hour in this bath and further stirred at room temperature for 2 hours. The reaction solution was diluted with an aqueous citric acid solution, followed by extraction with ethyl acetate. The organic layer was washed with water, saturated aqueous sodium bicarbonate, and saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography to obtain the compound of interest as a colorless oil substance (389 mg).

1. stirringthe mixture was then stirred for 1 hour in this bath
2. stirringfurther stirred at room temperature for 2 hours
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with water, saturated aqueous sodium bicarbonate, and saturated saline
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThen, the solvent was distilled off under reduced pressure
7. customthe obtained residue was purified by silica gel column chromatography
8. customto obtain the compound of interest as a colorless oil substance (389 mg)

ORD record

ord-eb1f7eb66a3f4a67a185b605e536500d

Source dataset

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07947738B2