Hydrochloric Acid → HCID 67188417, compound

HRID 551788Notes

Reaction equation

HRID 551788 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]2[CH2:12][CH2:11][N:10]([C:13]([N:15]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[O:18][CH2:17][CH2:16]3)=[O:14])[CH2:9]2)[CH:3]=1>CCOCC>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]2[CH2:12][CH2:11][N:10]([C:13]([N:15]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[O:18][CH2:17][CH2:16]3)=[O:14])[CH2:9]2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24852911HCID 24852911, compound

Product 1

HCID 67188417HCID 67188417, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

5.82 ml of a 0.2N solution of hydrochloric acid in ether are added to a 25 ml round-bottomed flask comprising 0.18 g of 4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazine. Stirring is maintained for 10 min. After evaporating, the residue is taken up in ether. The precipitate is filtered off and then dried under vacuum. 0.12 g of 4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is obtained.

Workup

  1. temperatureis maintained for 10 min
  2. customAfter evaporating
  3. filtrationThe precipitate is filtered off
  4. customdried under vacuum

Sources & evidence

ORD record
ord-ff1a26fc292f4d919b57d9664e0fbc0b
Source dataset
uspto-grants-2011_05
Patent number
US07947834B2

Reaction notes

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