反应详情

15.4 g of 1,1′-carbonyldimidazole, 125 ml of tetrahydrofuran and 9.43 ml of 1,2,3,4-tetrahydroquinoline are introduced into a 500 ml round-bottomed flask. The reaction medium is brought to reflux for 20 hours. The solvent is evaporated under reduced pressure and the residue is taken up in ethyl acetate and then washed with water. The organic phase is dried over sodium sulfate and the solvent is evaporated under reduced pressure to result in 16.04 g of 1-(1H-imidazol-1-ylcarbonyl)-1,2,3,4-tetrahydroquinoline.

1. temperatureto reflux for 20 hours
2. customThe solvent is evaporated under reduced pressure
3. washwashed with water
4. dry with materialThe organic phase is dried over sodium sulfate
5. customthe solvent is evaporated under reduced pressure
6. customto result in 16.04 g of 1-(1H-imidazol-1-ylcarbonyl)-1,2,3,4-tetrahydroquinoline