Chlorotrimethylsilane → N2-Methoxytrityl-9-[(2R)-2-deoxy-2-C-ethynyl-2-fluoro-beta-D-erythro-pentofuranosyl]guanine

HRID 552082Notes

Reaction equation

HRID 552082 reaction equation
[C:1]([C@@:3]1([F:21])[C@H:7]([OH:8])[C@@H:6]([CH2:9][OH:10])[O:5][C@H:4]1[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][CH:14]=[N:15][C:16]=2N)#[CH:2].C[Si](Cl)(C)C.CO[C:29]1[CH:48]=[CH:47][CH:46]=[CH:45][C:30]=1[C:31](Cl)([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.[NH4+:49].[OH-:50].C([O:54][CH2:55]C)(=O)C>N1C=CC=CC=1>[CH3:55][O:54][N:49]([C:31]([C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:30]1[CH:29]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:14]1[NH:15][C:16](=[O:50])[C:17]2[N:18]=[CH:19][N:11]([C@@H:4]3[O:5][C@H:6]([CH2:9][OH:10])[C@@H:7]([OH:8])[C@@:3]3([C:1]#[CH:2])[F:21])[C:12]=2[N:13]=1

Participants

7

Reactant 5

HCID 6397ChlorotrimethylsilaneHCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 14429619Methoxytrityl chlorideHCID 866247809-[(2R)2-Deoxy-2-C-ethynyl-2-fluoro-beta-D-erythro-pentofuranosyl]adenine

Product 1

HCID 136343925N2-Methoxytrityl-9-[(2R)-2-deoxy-2-C-ethynyl-2-fluoro-beta-D-erythro-pentofuranosyl]guanine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a stirred solution of 7i (5.18 mmol) in pyridine (7 ml/mmol) was added trimethylsilyl chloride at room temperature. The mixture was stirred at room temperature for 6 hours. Methoxytrityl chloride (6.21 mmol) was then added and the reaction mixture was stirred at room temperature for 16 hours and 2 hours with NH4OH (4 ml/mmol). The mixture was diluted with ethyl acetate, washed with H2O, sat NaHCO3 solution and sat NaCl solution, dried over Na2SO4, filtered and evaporated. The crude material was purified by silica gel chromatography (DCM/MeOH) to yield the title compound. Yellowish oil. Molecular Formula C32H28FN5O5.

Workup

  1. washwashed with H2O
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated
  5. customThe crude material was purified by silica gel chromatography (DCM/MeOH)

Sources & evidence

ORD record
ord-7d33f0a210e14f1b8f2c9ab0910b7809
Source dataset
uspto-grants-2011_05
Patent number
US07951789B2

Reaction notes

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