Hydrochloric Acid → Piperazine, 1-(3,4-dihydroxybenzoyl)-4-methyl-

HRID 5522Notes

Reaction equation

HRID 5522 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:23])[C:9]2[CH:14]=[CH:13][C:12]([O:15]C(=O)C)=[C:11]([O:19]C(=O)C)[CH:10]=2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].Cl>CO>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:23])[C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:19])[CH:10]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 150773061-Methyl-4-(3,4-diacetoxybenzoyl)piperazine

Product 1

HCID 3062451Piperazine, 1-(3,4-dihydroxybenzoyl)-4-methyl-Yield 32.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1-methyl-4-(3,4-diacetoxybenzoyl)piperazine (295 mg) n methanol (3 ml) was added a saturated potassium carbonate solution is methanol (6 ml) and the mixture was stirred at room temperature for 30 minutes. The mixture was poured into ice water and adjusted to pH 9 with 1N hydrochloric acid. The mixture was extracted several times with a mixture of chloroform and methanol (20:1 V/V) and the organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized by addition of ethyl acetate to give 1-methyl-4-(3,4-dihydroxybenzoyl)piperazine (71 mg) as white crystal.

Workup

  1. extractionThe mixture was extracted several times
  2. additionwith a mixture of chloroform and methanol (20:1 V/V)
  3. washthe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe residue was crystallized by addition of ethyl acetate

Sources & evidence

ORD record
ord-a8eca58fbacb432c81e4d18ca5413a11
Source dataset
uspto-grants-1993_09
Patent number
US05244890

Reaction notes

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