HRID552243

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31268

Pyrrolidine

C4H9N

HCID517165

Ammonium acetate

C2H7NO2

结构：CC1(C)CN(CC(=O)O)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11384512

(5S)-5-[[(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholineacetic acid

C20H21ClN4O4

PRODUCTS

生成物

结构：CC1(C)CN(CC(=O)N2CCCC2)[C@H](C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)CO1

HCID11784671

未命名化合物

收率 82%

PROCEDURE

实验过程

The desired compound was prepared according to Method F from [(S)-5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and pyrrolidine in 82% yield. 1H-NMR (300 MHz, DMSO-d6): δ 1.21 (s,3H), 1.29 (s,3H), 1.75-1.92 (m,4H), 2.46 (d,1H), 2.77 (d,1H), 3.35-3.68 (m,7H), 3.94 (m,2H), 8.08 (s,1H), 8.19 (d,1H), 8.23 (s,1H), 8.41 (d,1H), 9.05 (s,1H), 10.71 (s,1H), 11.51 (s,1H). Retention Time (LC, method: ammonium acetate standard): 1.75 min. MS (M+H+): 470.3.

WORKUP

后处理

custom1.75 min