反应详情

2-amino-3-iodo-6-chloropyridine (2 g, 7.874 mmol) is taken up in isopropanol (30 mL) under N2. Diethoxy-2-bromoacetal (2.5 mL, 15.748 mmol, 2 equiv.) is added to the suspension followed by HBr 48% (2 mL). The resulting mixture is then refluxed for 12 h and cooled down to room temperature. The mixture is partly concentrated under vacuum and the resulting slurry is taken up in diethyl ether which causes the precipitation of a solid that is separated by filtration and washed with little amounts of diethyl ether to afford the desired material as a powder.

1. temperatureThe resulting mixture is then refluxed for 12 h
2. concentrationThe mixture is partly concentrated under vacuum
3. customthe precipitation of a solid
4. customthat is separated by filtration
5. washwashed with little amounts of diethyl ether