反应详情

To a solution of 4-fluoronitrobenzene (5.00 g, 35.4 mmol) in THF (50 mL), 1-isopropylpiperazine (4.54 g, 35.4 mmol) and K2CO3 (7.35 g, 53.2 mmol) are added. The reaction mixture is stirred at room temperature overnight. The solvent is removed under reduced pressure and the residue is partitioned between EtOAc and water. The organic layer is washed with brine, dried (MgSO4), filtered and the solvent is removed under reduced pressure. The crude compound is purified by silica gel column chromatography using 99:1 and 98:2 DCM:NH3 (7 M in MeOH) to give the title compound (8.2 g, 94%).

1. customThe solvent is removed under reduced pressure
2. customthe residue is partitioned between EtOAc and water
3. washThe organic layer is washed with brine
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customthe solvent is removed under reduced pressure
7. customThe crude compound is purified by silica gel column chromatography