Hydrogen Bromide → 4-Bromo-6-methylpyridine-2-carboxylic acid

HRID 552483Notes

Reaction equation

HRID 552483 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([N+]([O-])=O)[CH:3]=1.[BrH:14]>>[Br:14][C:4]1[CH:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 112753916-methyl-4-nitropicolinic acid

Product 1

HCID 534852954-Bromo-6-methylpyridine-2-carboxylic acid

Procedure

A solution of 3.6 g (19.6 mmol) of 6-Methyl-4-nitro-pyridine-2-carboxylic acid in 40 ml of 48% hydrobromic acid was heated at 100° C. overnight and then allowed to cool to room temperature. The solution was then evaporated to dryness in vaccuo. The crude material (10.5 g) containing inorganic salts was directly used in the next step.

Workup

  1. customThe solution was then evaporated to dryness in vaccuo
  2. additionThe crude material (10.5 g) containing inorganic salts

Sources & evidence

ORD record
ord-7534d19fc07f4379a371d23045f25060
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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