Phosphorus oxychloride → HCID 18689751, compound

HRID 552523Notes

Reaction equation

HRID 552523 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH2:10])=O)[N:6]=1.P(Cl)(Cl)(Cl)=O>CN(C=O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]#[N:10])[N:6]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 70640912-(2-amino-1,3-thiazol-4-yl)acetamide

Product 1

HCID 18689751HCID 18689751, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2.0 g (13.0 mmol) of 2-(2-Amino-thiazol-4-yl)-acetamide in 30 ml of dry DMF was added Phosphorus oxychloride (2.3 ml, 25.0 mmol, 2.0 equiv.) dropwise at 0° C.

Sources & evidence

ORD record
ord-96323deaafd94ef2a0bb7a3f45f00494
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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