反应详情

To a solution of 100 mg (0.40 mmol) of 4-(3,5-Difluorophenyl)-6-methyl-pyrimidine-2-carboxylic acid, and 2-Amino-thiazole-4-carboxylic acid methyl ester in 5 ml of dry Dimethylacetamide were added 0.34 ml N-Ethyldiisopropylamine and 141.7 mg (0.44 mmol) of o-(Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU). After stirring overnight at room temperature, the mixture was diluted with 15 ml of methylene chloride, and worked up according to standard procedures. The crude material was purified by flash chromatography on silicagel using an Ethyl acetate/Heptane 1:4 mixture as eluant to yield the title compound as a light yellow crystalline solid, MS (ISP): m/e=390.2 (M+H)+.

1. customThe crude material was purified by flash chromatography on silicagel