Phosphorus oxychloride → HCID 67165528, compound

HRID 552545Notes

Reaction equation

[C:1]([CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=3)[CH:16]=[C:15]([CH3:27])[N:14]=2)=[O:12])=[N:6]1)(=O)[NH2:2].O=P(Cl)(Cl)Cl>>[C:1]([CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=3)[CH:16]=[C:15]([CH3:27])[N:14]=2)=[O:12])=[N:6]1)#[N:2]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 24820980HCID 24820980, compound

Product 1

HCID 67165528HCID 67165528, compound

Procedure

The title compound, was prepared by treatment of 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (1-carbamoylmethyl-1H-pyrazol-3-yl)-amide with POCl3 in accordance with the general method of example 163, step 2 to yield the final compound as a white solid, MS (ISP): m/e=354.2 (M+H)+.

Sources & evidence

ORD record: ord-7961b904f64747d286c090e2be4cb0f2
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951824B2

Reaction notes

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