Sodium methanesulfinate → 4-(3-Methanesulfonyl-propoxy)-benzoic acid methyl ester

HRID 552577Notes

Reaction equation

HRID 552577 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13]Br)=[CH:6][CH:5]=1.[Na+].[CH3:17][S:18]([O-:20])=[O:19]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][S:18]([CH3:17])(=[O:20])=[O:19])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 2733271Sodium methanesulfinateHCID 3709742Methyl 4-(3-bromopropoxy)benzoate

Product 1

HCID 597867704-(3-Methanesulfonyl-propoxy)-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared in a manner substantially analogous to Procedure C starting from 4-(3-bromo-propoxy)-benzoic acid methyl ester and methanesulfinic acid sodium salt using DMF as solvent. MS (ES+) 273.1.

Sources & evidence

ORD record
ord-66209c1ee8e64b1b83ec6242d9ba51af
Source dataset
uspto-grants-2011_05
Patent number
US07951826B2

Reaction notes

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