反应详情

To 2.08 mmol 5-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoic acid methyl ester in 2.2 ml THF and 2.2 ml water was added 3.12 mmol lithium hydroxide and the reaction mixture was stirred at RT for 2 hours. After such time the solvent was removed in vacuo, the residue was taken in water and acidified by addition of 3N HCl to yield after filtration the title compound as a white solid (88%). MS (m/e): 279.1 ([M−H], 100%).

1. customAfter such time the solvent was removed in vacuo
2. additionacidified by addition of 3N HCl
3. customto yield
4. filtrationafter filtration the title compound as a white solid (88%)