Diisopropylethylamine → HCID 178478406, compound

HRID 552714Notes

Reaction equation

HRID 552714 reaction equation
[NH2:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[Cl:11][C:12]1[N:20]=[C:19]2[C:15]([NH:16][CH:17]=[N:18]2)=[C:14](Cl)[N:13]=1.C(N(CC)C(C)C)(C)C>C(O)C>[Cl:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][NH:18]2)=[C:14]([NH:1][C@@H:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3]2)[N:13]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 53244122,6-DichloropurineHCID 70000841-Aminoindane, (S)-

Product 1

HCID 178478406HCID 178478406, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)-(+)-1-Aminoindane (266.0 mg, 2.0 mmol), 2,6-dichloropurine (380 mg, 2.0 mmol) and N,N-diisopropylethylamine (380 μL, 2.2 mmol), were dissolved in Ethanol (4.0 mL) and reacted in a microwave at 120° C. for 600 s. A yellow solid formed which was filtered, washed with ethanol (20 mL) and dried to give the title compound 0.455 g, 80% yield.

Workup

  1. customreacted in a microwave at 120° C. for 600 s
  2. customA yellow solid formed which
  3. filtrationwas filtered
  4. washwashed with ethanol (20 mL)
  5. customdried

Sources & evidence

ORD record
ord-66a5b82ee7ad45e3aae907941fd0369b
Source dataset
uspto-grants-2011_05
Patent number
US07951810B2

Reaction notes

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