Potassium Carbonate → HCID 21864458, compound

HRID 552737Notes

Reaction equation

HRID 552737 reaction equation
C[Si]([C:5]#[C:6][C:7]1[C:15]2[CH:14]=[N:13][CH:12]=[N:11][C:10]=2[NH:9][CH:8]=1)(C)C.C(=O)([O-])[O-].[K+].[K+]>CO.CCOC(C)=O>[C:6]([C:7]1[C:15]2[CH:14]=[N:13][CH:12]=[N:11][C:10]=2[NH:9][CH:8]=1)#[CH:5]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 67164188HCID 67164188, compound

Product 1

HCID 21864458HCID 21864458, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

5-[(trimethylsilyl)ethynyl]-7H-pyrrolo[2,3-d]pyrimidine (0.320 g, 1.49 mmol) and potassium carbonate (0.513 g, 3.72 mmol) were stirred in MeOH (6 mL) for 18 hours. The mixture was diluted with EtOAc, washed with saturated ammonium chloride, brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give the title compound as an orange solid (0.185 g, 87%).

Workup

  1. washwashed with saturated ammonium chloride, brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-02be7064000e46808272030d832a6cd0
Source dataset
uspto-grants-2011_05
Patent number
US07951810B2

Reaction notes

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