反应详情

To a solution of 2-fluoroterephthalonitrile (500 mg) and Et3N (572 μl) in EtOH (20 ml) was added hydrazine (monohydrate), followed by reaction at 60° C. for 16 hours, and concentrated. The residue was washed with diethyl ether to obtain 3-amino-1H-indazole-6-carbonitrile (488 mg) as a yellow solid.

1. customfollowed by reaction at 60° C. for 16 hours
2. concentrationconcentrated
3. washThe residue was washed with diethyl ether