反应详情

温度

0 °C

To a solution of 60% NaH (12.38 g) in DMF (480 ml) was added a solution of 1H-indole-4-carbonitrile (40.0 g) in DMF (80 ml) at 0° C. After stirring at 0° C. for 30 min, it was stirred at room temperature for 0.5 hour. Thereafter, a solution of 2-bromoacetamide (40.76 g) in DMF (80 ml) was added dropwise thereto at 0° C. The solution was warmed from 0° C. to room temperature, and stirred for 12 hours. To the reaction solution was added water (1200 ml), and the precipitated white solid was collected by filtration. The solution was washed with hot water (300 ml) and diisopropyl ether (200 ml) to obtain 2-(4-cyano-1H-indol-1-yl)acetamide (52.1 g) as a white solid.

1. stirringit was stirred at room temperature for 0.5 hour
2. customat 0° C
3. temperatureThe solution was warmed from 0° C. to room temperature
4. stirringstirred for 12 hours
5. filtrationthe precipitated white solid was collected by filtration
6. washThe solution was washed with hot water (300 ml) and diisopropyl ether (200 ml)