HCID 54542739, compound → 3-(6-Carboxy-3-hydroxy-2-pyridyl)-propionic acid

HRID 55293Notes

Reaction equation

HRID 55293 reaction equation
C[O:2][C:3](=[O:18])[CH2:4][CH2:5][C:6]1[C:11]([O:12]C)=[CH:10][CH:9]=[C:8]([C:14]([O:16]C)=[O:15])[N:7]=1>Br>[C:14]([C:8]1[N:7]=[C:6]([CH2:5][CH2:4][C:3]([OH:18])=[O:2])[C:11]([OH:12])=[CH:10][CH:9]=1)([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 54542739HCID 54542739, compound

Product 1

HCID 199574893-(6-Carboxy-3-hydroxy-2-pyridyl)-propionic acidYield 75.6%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

Under the conditions of example 16K, 6.5 g of 3-(3-methoxy-6-methoxycarbonyl-2-pyridyl)-propionic acid methyl ester in 60 ml of 48% hydrobromic acid is reacted and worked up. 4.1 g of 3-(6-carboxy-3-hydroxy-2-pyridyl)-propionic acid of melting point 210°-212° C. is obtained.

Sources & evidence

ORD record
ord-7be800e0f7bb4867a4b32027d58d7214
Source dataset
uspto-grants-1997_04
Patent number
US05624943

Reaction notes

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