反应详情

The N-(2-ethoxycarbonylethyl)-4-(5-benzoylbenzimidazol-2-yl)-3,5-dimethylpyrrole-2-carboxamide (300 mg) obtained in Example 19 was dissolved in tetrahydrofuran (5 ml) and ethanol (5 ml), and a 4 N sodium hydroxide aqueous solution (10 ml) was added to the solution and stirred at room temperature for 1 hour. The reaction mixture was neutralized with a 4 N hydrochloric acid solution, and then the precipitate was collected by filtration. The solid was dried in vacuo to afford N-(2-carboxyethyl)-4-(5-benzoylbenzimidazol-2-yl)-3,5-dimethylpyrrole-2-carboxamide (211 mg, 75%) as a purple solid.

1. filtrationthe precipitate was collected by filtration
2. customThe solid was dried in vacuo