反应详情

温度

120 °C

Sodium hydrogen sulfite (101 mg) and the 5-formyl-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester (146 mg) obtained in Example 53 (1) were added to an N,N-dimethylacetamide (5 ml) solution of 3,4-diaminobenzophenone (160 mg). The mixture was heated to 120° C. and stirred for 10 hours. The reaction mixture was allowed to cool to room temperature, and then a 5% sodium carbonate (6 ml) was added and stirred at room temperature. The precipitate was collected by filtration to afford 5-(5-benzoylbenzimidazole-2-yl)-2,4-dimethylpyrrole-3-carboxylic acid ethyl ester (248 mg, 85%) as a light yellow solid.

1. temperatureto cool to room temperature
2. stirringstirred at room temperature
3. filtrationThe precipitate was collected by filtration